9/17/2023 0 Comments New colony six rarCell death in beta 4 transduced MDA-MB-231 cells was accompanied by metaphase chromosome decondensation and breakage suggestive of mitotic catastrophe. In both retinoid sensitive and resistant cells, expression of full-length beta 2 and beta 4 isoforms results in elevated sensitivity to retinoic acid treatment and caspase-independent cell death. Expression of the truncated beta prime isoform induces resistance to retinoic acid treatment in retinoid sensitive MCF7 cells. To determine the effects of different retinoic acid receptor isoforms on cell proliferation and apoptosis, we transduced retinoid sensitive (MCF7) and retinoid-resistant (MDA-MB-231) cells with retinoic acid receptor beta 2, beta 4, or beta prime. However, beta prime is able to heterodimerize and interact with transcription cofactors. Beta prime lacks the N-terminal domains of beta 2 and beta 4, including the DNA-binding domain. We previously reported the existence of a truncated isoform of the retinoic acid receptor beta, termed beta prime.
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